Thirdly, the dysregulation of protective molecular stabilizers is also crucial; particularly, deficiency of the cold-inducible RNA-binding protein (CIRP) as an important physiological stabilizer that causes a pro-arrhythmic condition by activating potassium channels, quickening repolarization, shortening the action potential duration, and consequently predisposing to arrhythmia like atrial fibrillation (Xie et al., 2020a; Xie et al., 2020b). This evidence concerns the gene KCNA3 and atrial fibrillation.