Multiple studies have reported significant correlation between p.H63D variant of HFE and ALS risk.67-70 The p.H63D variant has been shown to cause reduced SOD1 levels and increase disease duration in sALS patients.71 More recently, Canosa et al. (2023)72 demonstrated that patients harbouring SOD1 mutations along with p.H63D HFE variant exhibited significantly longer survival durations. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.