ADCYAP1 and migraine disorder: However, a Danish provocation study demonstrated hypersensitivity to PACAP-38 in persistent PTH attributed to mTBI.51 While not in the context of mTBI populations, conflicting findings have emerged regarding PACAP in individuals prone to migraines, as some studies indicate lower levels compared to healthy controls.52 Tuka et al.52 discovered a significantly lower concentration of PACAP-38 in patients with migraine during the interictal period (phase between migraine attacks) compared to healthy controls, with concentrations increasing during migraine attacks.