Individuals with mTBI who have elevated serum hsCRP (>1.10 mg/L, measured within 30 days post-injury) have reported a significantly higher incidence of headaches at their initial presentation.64 However, a separate study observed no correlation between elevated baseline plasma hsCRP levels in acute mTBI and the persistence of headaches up to 3 months (one headache per week).65 These conflicting results suggest that it remains inconclusive as to whether hsCRP is specific to PTH, and these inconsistent results may be due to inadequate controls for biological and methodological variability. The gene discussed is PTH; the disease is Headache.