Among them, a specific subgroup of microglia, which is referred to as disease-associated microglia (DAM), the transition of which is regulated by triggering receptor expressed on myeloid cells 2 (Trem2), is demonstrated to play critical roles at various stages of neurodegenerative diseases in the central nervous system (CNS) (Samant et al., 2024; Rangaraju et al., 2018). Here, TREM2 is linked to neurodegenerative disease.