MG has previously been demonstrated to correlate well with invasively measured MG23 and serves as an important prognostic marker in both rheumatic20 and degenerative calcified MV disease.24 Our virtual patients demonstrate a non-linear increase in MG as MV EOA decreases, which is consistent with Bernoulli’s law and clinical observations.9,21 Furthermore, our findings suggest that MG is a relatively reliable marker for MS severity under constant flow conditions. This evidence concerns the gene TMEM109 and myeloid sarcoma.