Conversely, long‐term survivors of pancreatic ductal adenocarcinoma exhibit significantly increased microbiome α‐diversity, with specific tumor microbiome members (Pseudoxanthomonas, Streptomyces, Saccharopolyspora, and Bacillus clausii) orchestrating favorable antitumor immune microenvironments by promoting CD8+ T cell activation and infiltration into tumor tissues, further confirming the value of intratumoral microbial communities as potential biomarkers for predicting immunotherapy prognosis [54]. The gene discussed is CD8A; the disease is neoplasm.