In addition, HPV in head and neck squamous cell carcinoma (HNSCC) tumor tissues was also associated with the infiltration of a variety of immune cells, including IL‐17+ CD8+ T lymphocytes, IFN‐γ+ CD8+ T lymphocytes, naive CD4+ T lymphocytes, and myeloid DCs. This evidence concerns the gene CD8A and head and neck squamous cell carcinoma.