Among the autoimmune disorders, CD risk variants were particularly highly enriched within the active PIRs of both ILC3s and CD4+ T cells (~2.3-fold enrichment in both cell types, p-value = 1.41 × 10−8 in ILC3s and p-value = 2.41 × 10−10 in CD4+ T cells). Here, CD4 is linked to autoimmune disease.