ABCA7 (ATP-binding cassette subfamily A member 7), associated with both L1 and Alu elements at 140 kb, is crucial for microglial-mediated amyloid-β clearance, with loss-of-function variants conferring the highest AD risk after APOE-ε4 (Reitz et al., 2013; De Roeck et al., 2017). Here, APOE is linked to Alzheimer disease.