The top AD genes by TE proximity included UCN, PLEKHA1, and FIS1 (3 TEs each), followed by PTK2B, PDCL3, and ABCA7 (2 TEs each) (Supplementary Figure S6D), with several genes showing cell-type-specific TE associations that may contribute to selective neuronal vulnerability in AD. The gene discussed is PTK2B; the disease is Alzheimer disease.