Figure 1B depicts the chromosomal distribution of copy number variations in tryptophan metabolism—related genes. We further investigated the differential expression level of tryptophan metabolism-related genes were evaluated between AML tumors and normal tissues. The results revealed that multiple TRPRGs exhibited higher expression in tumor tissues, such as ECHS1 and HADH (Figure 1C). Here, HADH is linked to acute myeloid leukemia.