Additional new adverse signals not mentioned in the drug inserts included death, renal impairment, dizziness, acute kidney injury, urine albumin/creatinine ratio increased, renal failure, blood creatine increased, urine albumin/creatinine ratio decreased, albuminuria, proteinuria, blood potassium decreased, glomerular filtration rate increased, albumin urine present, blood pressure systolic increased, blood urea increased, renal pain, thirst, protein urine present, acidosis, blood pressure diastolic increased and feeling drunk. This evidence concerns the gene ALB and Renal insufficiency.