It was also shown to increase the expression of COX-2 encoding cyclooxygenase-2 to inhibit ultraviolet B (290–320 nm)-induced skin cancer growth and epidermal thickening, however, the experiment used a mouse skin cancer model induced by ultraviolet radiation, which is different from the pathological process of spontaneous human skin cancer (Lee et al., 2017). The gene discussed is PTGS2; the disease is skin neoplasm.