Zhao et al. used two experimental animals, hamsters and mice, to verify the effect of Emodin succinate monoethyl ester on MAFLD, and the research results showed that, Emodin succinate monoethyl ester activates AdipoR2, AMPK and PPARα and reduces lipid deposition and hepatic steatosis. This evidence concerns the gene ADIPOR2 and Hepatic steatosis.