Liao et al. have found that isoliquiritigenin inhibited the activation of NF-κB and reduced the expressions of prostaglandin-endoperoxide synthase 2 (PTGS2), TNF-α, and nitric oxide synthase 2 (NOS2) in the colon tissues of 5-FU-induced CID mice, as well as repaired the integrity of intestinal mucosal barrier through restoring the height of intestinal villi and alleviating edema in intestinal epithelium (Liao et al., 2022). Here, TNF is linked to combined immunodeficiency.