Exosomes contribute to the angiogenic process in cancer progression by transporting various pro-angiogenic biomolecules, such as VEGF, matrix metalloproteinases (MMPs), and microRNAs, while also downregulating factors that inhibit hypoxia-inducible factor 1 (HIF-1) (Olejarz et al., 2020). Here, HIF1A is linked to cancer.