CD8A and neoplasm: Consequently, tumor-derived exosomes modulate antitumor immune responses by delivering materials such as mRNA, miRNA, and DNA, which inhibit T-cell activation and proliferation, increase the presence of regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and suppress the function of natural killer (NK) and CD8+ T-cells, thereby effectively evading the host immune system (Zandberg et al., 2024; Zabeti et al., 2024).