These vascular phenotypes in mice are consistent with hypertension-related microvascular structural remodeling and dysfunction (Humar et al., 2009), suggesting that the effects of XPNPEP2 on EC function and angiogenesis could explain some of the etiology of cardiovascular diseases caused by XPNPEP2 defects. This evidence concerns the gene XPNPEP2 and hypertensive disorder.