Similarly, ALDH18A1, a key enzyme in the de novo synthesis of proline and arginine, plays a crucial role in tumor metabolic reprogramming (Hu et al., 2008; Liu et al., 2015), Previous studies have shown that ALDH18A1 promotes the proliferation of hepatocellular carcinoma by influencing glycolysis and the pentose phosphate pathway (Ding et al., 2020). The gene discussed is ALDH18A1; the disease is neoplasm.