ALDH18A1 and hepatocellular carcinoma: Similarly, ALDH18A1, a key enzyme in the de novo synthesis of proline and arginine, plays a crucial role in tumor metabolic reprogramming (Hu et al., 2008; Liu et al., 2015), Previous studies have shown that ALDH18A1 promotes the proliferation of hepatocellular carcinoma by influencing glycolysis and the pentose phosphate pathway (Ding et al., 2020).