PI3K/AKT activation has been shown to promote tumor-enhancing autophagy (Li et al., 2024) and to facilitate oncogenesis by repressing or functionally impairing key autophagy mediators such as Beclin-1, LC3, and p62 (Cocco et al., 2022; Wang et al., 2023). The gene discussed is AKT1; the disease is neoplasm.