Notably, Zhang et al. found that levels of exosomal ANLN, ITGA6, and KRT18 were decreased in pancreatic carcinoma patients, suggesting that the serum exosomal ANLN/ITGA6/KRT18/MMP9 RNA combination could serve as a novel non-invasive diagnostic tool for digestive system cancers (Zhang et al., 2022b). This evidence concerns the gene ANLN and digestive system cancer.