IIn oral squamous cell carcinoma, ANLN knockdown increases expression of epithelial markers such as cadherin-1(CDH1) and claudin-1(CLDN1), while reducing mesenchymal markers including vimentin, SNAIL1, and SNAIL2, leading to attenuated EMT (Wu et al., 2024). The gene discussed is CLDN1; the disease is oral cavity squamous cell carcinoma.