While other MMPs, such as MMP-2, have been associated with the progression of glioblastoma, this study aims to evaluate the specific potential of MMP-9 as a biomarker (8), its correlation with tumor edema volume, which may indicate tumor invasiveness, and its association with overall survival (OS) in glioblastoma and BM patients are examined. The gene discussed is MMP9; the disease is glioblastoma.