Activated platelets also release large amounts of platelet-derived growth factor (PDGF) (21), transforming growth factor-β (TGF-β), and vascular endothelial growth factor (VEGF) (22), strongly stimulating tumor cell proliferation, epithelial-mesenchymal transition, and fibrosis, and promoting tumor angiogenesis. This evidence concerns the gene TGFB1 and neoplasm.