Following the injection of sh-TBX21, no significant changes were observed on the clusters of PD-1+CD4+ T cells, Tim-3+CD4+ T cells, Lag-3+CD4+ T cells, PD-1+CD8+ T cells, Tim-3+CD8+ T cells, and Lag-3+CD8+ T cells in tumor tissues (Figures 5A, B). The gene discussed is LAG3; the disease is neoplasm.