Dermatomyositis (DM) is classified into five distinct subtypes based on muscle-specific autoantibodies (MSAs), including nuclear matrix protein (NXP) 2, transcription intermediary factor (TIF)1-γ, nucleosome-remodeling and deacetylase complex (also known as Mi2), melanoma differentiation-associated gene 5 (MDA5), and small ubiquitin-like modifier-activating enzyme (SAE) (1). The gene discussed is TRIM33; the disease is dermatomyositis.