Among the 11 candidate biomarkers, seven genes (i.e., IFI44, IFI35, IFI27, IFIT3, OAS3, TNFSF10, and EPSTI1) with no previous reports of association with ZIKV infection were selected for functional verification via siRNA-mediated gene knockdown. The gene discussed is IFI27; the disease is Zika virus infectious disease.