SHROOM4 and lung cancer: And mRNA expression of SHROOM4 exhibited the most greatest difference in mRNA expression in lung cancer (95% CI: -2.4887–2.3058, difference -2.2626) (Figure 1A), especially notable in patients with LUAD (95% CI: -2.0555–1.5456, difference -1.7991) and LUSC (95% CI: -2.9622–2.4744, difference -2.7234).