PPARGC1A and Alzheimer disease: (33) also demonstrated synergistic upregulation of AMPK/PGC-1α/SIRT1 signaling in the hippocampus of Alzheimer’s disease (AD) rats treated with aerobic treadmill exercise (6–18 m/min, 5 days/week for 8 weeks) and resveratrol (20 mg/kg/day), resulting in improved mitochondrial resilience and neuroprotection.