In a population of 240 healthy men and women, 22–93 years old, who were disease- and treatment-free and had no physical and cognitive impairment, eight proteins - Follicle-Stimulating Hormone (FSH), Sex Hormone-Binding Globulins (SHBG), Tissue Factor Pathway Inhibitor (TFPI), Luteinizing Hormone (CGA/LHB), Vitamin K-dependent protein 5 (PROS1), human Chorionic Gonadotropin (CGA/CGB), Netrin-4 (NTN4), and Insulin-like Growth Factor Binding Protein 7 (IGFBP7) - were differently associated by age and sex (21). The gene discussed is IGFBP7; the disease is Cognitive impairment.