Compared to monocytes from healthy volunteers, monocytes from patients in the ICU with sepsis had a significantly lower expression of proteins associated with the antigen presentation pathway (HLA-DR, HLA-DP, HLA-DR antigen-associated invariant chain (CD74)) and co-stimulation (CD86), cytokines (TNF-α and IL-10), NOX-2, and NF-kB (p65) (adjusted p <0.05 for all). Here, CD74 is linked to Sepsis.