The NF-κB and ERK signaling pathways are well-recognized regulators of immune-related gene expression and play pivotal roles in neuroinflammatory cascades mediated by glial cells during the progression of neurodegenerative disorders, including AD disease, Parkinson’s disease, and amyotrophic lateral sclerosis (Chen et al., 2012; Albert-Gasco et al., 2020). The gene discussed is NFKB1; the disease is Parkinson disease.