The NF-κB and ERK signaling pathways are well-recognized regulators of immune-related gene expression and play pivotal roles in neuroinflammatory cascades mediated by glial cells during the progression of neurodegenerative disorders, including AD disease, Parkinson’s disease, and amyotrophic lateral sclerosis (Chen et al., 2012; Albert-Gasco et al., 2020). This evidence concerns the gene NFKB1 and amyotrophic lateral sclerosis.