NPPB and hydrops fetalis: This group had significantly more severe disease than the other two types, with the proportion of NYHA class IV reaching 20.5% (compared to only 5.0% in the Active Management Type) and a median NT-proBNP level as high as 12,500 pg/mL (compared to 3,850 pg/mL in the Active Management Type), indicating they are in the advanced stages of HF with severely impaired cardiac function.