INS and Stroke: While the exact mechanisms underlying the association of elevated TyG-BMI index and hsCRP with CVD, stroke, and cardiac events remain unclear, they may be explained at least partly as follows: (1) Elevated hsCRP may facilitate IR via the excessive release of proinflammatory cytokines, such as IL-1β, activating the innate immune system (39); (2) High circulating insulin concentrations could reduce the production of nitric oxide by activating serum and glucocorticoid kinase 1.