Search keywords and medical subject headings included IgA nephropathy, APRIL, BAFF, sibeprenlimab, atacicept, povetacicept, telitacicept, complement inhibition, iptacopan, cemdisiran, ravulizumab, precision medicine, and Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. The gene discussed is TNFSF13B; the disease is IgA glomerulonephritis.