rs1330225 (PRMT6) linked to high DBP/MAP during low-sodium; rs10930597 (CDCA7) and rs8002688 (PIBF1) linked to high MAP during low-sodium/potassium; rs16890334 (IRAK1BP1) linked to high SBP during high-sodium/potassium; rs11887188 (ARL4C) and rs2030114 (SALL1) linked to DBP during potassium; rs7577262 (TRPM8) linked to SBP response to cold pressor test; rs17135875 (FBXL13) linked to MAP response to cold pressor test. Dose-response observed between risk alleles and incident HTN over 7.5 years. This evidence concerns the gene IRAK1BP1 and hypertensive disorder.