Novel HTN-associated genes including SLC4A7, TBX2, PTK2B, UBE2E2, RAMP1, MECOM, PRKCA, MAPK1, ACVR1C, alongside replication of known loci ATP2B1, CACNB2, CYP17A1, SH2B3, CSK, MOV10. Here, MECOM is linked to hypertensive disorder.