rs3184504 (SH2B3) as the principal shared SNP between HTN and stroke. Following imputation, 16 shared genes were detected, including ALDH1A2, ALDH2, APOA5, ATXN2, CNNM2, CUBN, CYP17A1, LPL, NT5C2, PHACTR1, PITX2, SH2B3, and ZPR1. This evidence concerns the gene ALDH2 and hypertensive disorder.