Identified five overlapping genes (KCNMA1, MPDZ, TCF21, WWOX, CACNA1D) forming the shared genomic background of obesity-related HTN. Reduced renal KCNMA1 expression may serve as a molecular marker and therapeutic target for hypertensive obesity. The gene discussed is MPDZ; the disease is obesity due to melanocortin 4 receptor deficiency.