Significant variants included rs3753584, rs4845875, and rs6540997 near NPPA associated with increased ANP (MR-proANP); rs198379 near NPPB linked to BNP; rs7000551 near PPP3CC associated with BNP:NT-proBNP ratio; and rs11105298/rs61378614 near GALNT4 also influencing this ratio. Only NPPA-related alleles that elevate ANP were significantly associated with lower BP and reduced HTN risk. This evidence concerns the gene GALNT4 and hypertensive disorder.