Novel HTN-associated genes including SLC4A7, TBX2, PTK2B, UBE2E2, RAMP1, MECOM, PRKCA, MAPK1, ACVR1C, alongside replication of known loci ATP2B1, CACNB2, CYP17A1, SH2B3, CSK, MOV10. This evidence concerns the gene RAMP1 and hypertensive disorder.