rs3184504 (SH2B3) as the principal shared SNP between HTN and stroke. Following imputation, 16 shared genes were detected, including ALDH1A2, ALDH2, APOA5, ATXN2, CNNM2, CUBN, CYP17A1, LPL, NT5C2, PHACTR1, PITX2, SH2B3, and ZPR1. The gene discussed is NT5C2; the disease is hypertensive disorder.