The cardiometabolic overlap was most evident at immune/vascular and renal-transport loci: SH2B3 is associated with BP and immune-metabolic phenotypes; calcium-handling genes (ATP2B1 and CACNA1D/CACNB2) link vascular reactivity to cardiometabolic profiles; and renal loci (UMOD and SLC4A7) connect tubular sodium/bicarbonate handling with both hypertension and metabolic traits [32,46,53,58]. This evidence concerns the gene SH2B3 and hypertensive disorder.