ANP: atrial natriuretic peptide; BP: blood pressure; CKD: chronic kidney disease; DBP: diastolic blood pressure; DM: diabetes mellitus; DKD: diabetic kidney disease; ENaC: epithelial sodium channel; HTN: hypertension; LDL: low-density lipoprotein; MAP: mean arterial pressure; SBP: systolic blood pressure; SNP: single nucleotide polymorphism; T2DM: type 2 diabetes mellitus; VNTR: variable number tandem repeat. The gene discussed is NPPA; the disease is chronic kidney disease.