PRKG1 and hypertensive disorder: PRKG1 (rs1904694, rs7897633), CYP4A11 (rs1126742), and CYBA (rs4673) were linked to HTN. CYBA (rs4673) was associated with MAP elevation in hypertensives and SBP reduction during diuresis shrinkage, while CYP4A11 (rs1126742) was associated with DBP and MAP reduction in normotensives.