We applied this method to investigatethe interaction between transthyretin (TTR) and the amyloid beta (Aβ)peptide, a system of interest due to transthyretin’s proposedrole in the clearance of Aβ peptide, whose accumulation in thebrain is associated with Alzheimer’s disease. The gene discussed is TTR; the disease is early-onset autosomal dominant Alzheimer disease.