These findings further indicate that inhibiting the high expression of PCSK9 after AMI can alleviate myocardial fibrosis and that this process is associated with the TGF‐β signaling pathway (Figure 2g,hp < 0.0001; Figure 2i,jp < 0.01; Figure 2kp < 0.001; Figure 2lp <0.05; and Figure 2mp < 0.05). The gene discussed is PCSK9; the disease is Myocardial fibrosis.