(2012) first reported that dandelion root extract (DRE) selectively induces apoptosis in chronic myelomonocytic leukemia (CMML) cell lines through both extrinsic (caspase-8 activation) and intrinsic (mitochondrial depolarization, cytochrome c release) pathways, while sparing normal peripheral blood mononuclear cells (PBMCs). This evidence concerns the gene CASP8 and chronic myelomonocytic leukemia.