Although in recent years, significant progress has been made in the study of asthma genetics, revealing several potential genetic factors and therapeutic targets, for example, a Mendelian randomization study found that elevated levels of histone L2 (cathepsin L2) were significantly associated with an increased risk of asthma, which provided new insights into the pathomechanisms of asthma [4]. The gene discussed is CTSV; the disease is asthma.