AKT1 and schizophrenia: SEP-363856 (SEP-856), which is a new antipsychotic, may exert its antipsychotic effect in mice with schizophrenia-like behaviors induced by the MK-SI “dual-hit” model by promoting the restoration of synaptic plasticity, reducing the death of hippocampal neurons, decreasing the production of pro-inflammatory substances in the hippocampal region, and thereby initiating the PI3K/Akt/GSK-3β signaling cascade reaction (33).