PI16 and Sepsis: Additionally, cardiovascular and muscle-related proteins such as angiotensinogen (1.46, 95% CI: 1.03-2.08), α- and β-tropomyosin (0.68, 95% CI: 0.48-0.98), PI16 (0.72, 95% CI:0.54-0.97), and zyxin (0.61, 95% CI: 0.40-0.92) were elevated in cases.<h4>Conclusions</h4>Later mortality in children recovering from CSM is associated with persistent immune activation, a sepsis-like phenotype involving multiple systems.