Retinal IBA1+TMEM119+ resident microglia frequently surround or internalize Chlamydia pneumoniae inclusions, yet the proportion of CAM relative to bacterial burden is reduced by ~61% in AD compared with controls and inversely correlated to bacterial load, implying impaired microglial recognition and/or phagocytosis of infected cells. The gene discussed is TMEM119; the disease is Alzheimer disease.