Retinal NLRP3 and caspase-1 were very strongly and positively correlated with retinal atrophy severity, quantified as a thinning index from the inner limiting membrane to the outer limiting membrane (r = 0.82–0.86, p < 0.001–0.0001), and showed moderate positive correlations with global brain atrophy scores (r = 0.41–0.47, p < 0.05). Here, NLRP3 is linked to Retinal atrophy.