In addition, the combined retinal NLRP3 and Aβ42 index was the best predictor of MMSE score (Fig. 6C, r2 = 0.25), and retinal Aβ42 combined with either Chlamydia pneumoniae or CCasp3 also predicted MMSE (Fig. 6C, r2 = 0.22–0.23), while no individual marker predicted brain atrophy (Supplementary Fig. 13D). The gene discussed is NLRP3; the disease is Brain atrophy.