A shared subset [Reticulon-4 (RTN4), endoplasmic reticulum stress (TECR), dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3B, transmembrane emp24 domain-containing protein 4 (TMED4), AP2M1, heat shock protein β−1 (HSPB1), tropomyosin α−3 chain (TPM3), BAG3, LRRFIP1, ATPase H+ transporting V1 subunit G1(ATP6V1G1)] is altered in both AD retina and brain. The gene discussed is RTN4; the disease is Alzheimer disease.