NLRP3 and infection: Convergent evidence from MS-based proteomics, Chlamydia pneumoniae-infected cell cultures, and AD+ mouse models implicating this pathogen in cerebral NLRP3 inflammasome activation, together with prior murine infection studies demonstrating Chlamydia pneumoniae-driven NLRP3 activation21,22,58, led us to test whether a similar inflammasome axis and associated cell death mechanisms operate in the human AD retina.