AIF1 and Alzheimer disease: Our analysis revealed significant increases in 6E10+ Aβ plaques (1.6-fold, p < 0.001), IBA1+ microglia (1.3-fold, p < 0.01), and GFAP+ astrocytes (1.3-fold, p < 0.05) in the cortex of Chlamydia pneumoniae infected AD+ mice compared with PBS-administered AD+ mice (Fig. 3R).