Additionally, the DNA pathogen sensor and Chlamydia interactor, leucine-rich repeat-binding FLII interacting protein 1 (LRRFIP1), which positively regulates TLR4 by competing with FLII actin remodeling protein (FLII) for interaction with MYD8855, was upregulated in both the AD brain and retina (Fig. 2F and Supplementary Fig. 6A). This evidence concerns the gene TLR4 and Alzheimer disease.