NTN1 and Low back pain: Specifically, as osteoclasts remodel the calcified endplate generating pores, they create an acidic environment, become senescent and secrete factors, such as Netrin-1, that induce sensory innervation, causing LBP.13–18 Elimination of senescent cells with a senolytic drug significantly decreases sensory innervation and subsequently reduces LBP.16,17