PDE8B and hypothyroidism: GTEx colocalization analysis further confirmed their tissue-specific colocalization: with PP4 > 0.8 as the significance threshold, FAM227B colocalized significantly with hyperthyroidism GWAS signals in the adrenal gland, lung, and minor salivary gland; PDE10A colocalized significantly with hyperthyroidism signals in thyroid tissue; and PDE8B exhibited significant colocalization with both hyperthyroidism and hypothyroidism GWAS signals in thyroid tissue.