PDE10A and schizophrenia: PDE10A showed an extreme signal peak in the neurological disease category (phenotype group ID ~ 17,128) with −log10(P)=8.2 (P = 6.3 × 10 − 9), exceeding the genome-wide significance threshold (P < 5 × 10 − 8), supporting a strong genetic association with specific neuropsychiatric disorders (e.g., Parkinson’s disease or schizophrenia).