PDE8B and hyperthyroidism: Among hyperthyroidism-related genes, both PDE8B (phosphodiesterase 8B) and PDE10A (phosphodiesterase 10A) showed significant negative correlations (associated with reduced hyperthyroidism risk): the SMR effect size for PDE8B was −0.638 (P_SMR = 5.78 × 10 − 16), and for PDE10A was −0.505 (P_SMR = 6.78 × 10 − 7).