GTEx coloc analysis (with PP4 > 0.8 as the threshold) confirmed significant colocalization: FAM227B with hyperthyroidism signals in the adrenal gland, lung, and minor salivary gland; PDE8B with both hyperthyroidism and hypothyroidism signals in thyroid tissue; and PDE10A with hyperthyroidism signals in thyroid tissue. The gene discussed is PDE8B; the disease is hypothyroidism.