The shared DEG set was dominated by innate immune and inflammatory programs (pattern-recognition receptor signaling, cytokine/TNF-related signaling, cell-death modules, and NET-related pathways), while cardiometabolic signals included KEGG ‘Lipid and atherosclerosis’ and additional metabolism/redox- and endocrine-related pathways (Fig 2D–2G). The gene discussed is TNF; the disease is atherosclerosis.