Apolipoprotein E (APOE) represents the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD), the most common form of dementia (2024; Mayeux and Stern 2012; Morris et al. 2019; Rajan et al. 2017; Rizzi et al. 2014; Tiwari et al. 2019). Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.