ART regimens from eight classes of drugs are currently available to treat HIV infection.16 These include the nucleoside and nucleotide reverse-transcriptase inhibitors (NRTIs), nonnucleoside reverse-transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), integrase strand transfer inhibitors (INSTIs), a fusion inhibitor (FI), chemokine (C-C motif) receptor 5 (CCR5) antagonists (entry inhibitors), post-attachment inhibitors, and capsid inhibitors. This evidence concerns the gene CCR5 and HIV infectious disease.