TRPV1 and relapsing-remitting multiple sclerosis: The TRPV1 SNP rs222747 GG/GC genotype, associated with cortical excitability and pain modulation in MS patients, influences cerebrospinal fluid cytokine composition [53–55] However, in individuals with relapsing-remitting MS, the mRNA expression of TRPV1 and other TRP channels in peripheral blood mononuclear cells is decreased [56].