MAP2K7 and retinal detachment: MEK/ERK pathway inhibition (though relevant mostly to solid tumor drugs) is known to disrupt the retinal pigment epithelium and cause serious, or exudative, retinal detachment, sometimes accompanied by uveal effusion (46); interestingly, some TKIs like ponatinib that hit multiple kinases might also disturb retinal vasculature integrity via endothelial effects, contributing to RVO or hemorrhage (46).