PLK4 and hepatocellular carcinoma: Unsupervised clustering of TCGA-HCC patients based on the expression profiles of these 12 myc-DEGs (CDC45, PLK4, TYMS, NME1, CAD, FBL, IMPDH2, NOP56, NHP2, SRM, PRMT3, CNBP) stratified the cohort into three distinct clusters (C1–3) (Figure 1D).