In our study, after nutritional support, TNF-α, IL-6, and CRP levels in the OG were lower than those in the CG, suggesting that early EN combined with PN could effectively reduce the degree of inflammatory stress response in patients with GC after surgery, which is in line with the results of Mańkowska-Wierzbicka et al. (27). This evidence concerns the gene IL6 and gastric cancer.