Figure 3 shows the mediation analysis results, with FSH level as the independent variable and CERAD-K total scores as the dependent variable. The proposed mediator was the global cerebral Aβ retention (global mean SUVR value), given that cerebral Aβ retention is known to be an important risk factor for cognitive decline (Wirth et al., 2013). The analysis revealed no significant direct effect of FSH levels on CERAD-K total scores (β = −0.924, p = 0.355). However, the effect of FSH levels on CERAD-K total scores was mediated by global mean SUVR values (β = −0.0432, p = 0.006). Here, BRD2 is linked to Mental deterioration.