Mortality status at 8-years was consistently elevated in these patients: decompensated liver disease (platelets < 100,000/μL [32.8%], albumin < 3 g/dL [32.6%], total bilirubin > 4 μmol/L [22.4%], NH3 > 20 [34.4%]), AIDS or untreated HIV infection (HIV viral load > 10,000 copies [37.9%], CD4 < 200 cells/μL [29.4%]), advanced kidney disease (creatinine > 4 mg/dL [44.1%]), substance use disorder (positive urine amphetamine [41%], urine cocaine [40%]), uncontrolled diabetes (hemoglobin A1C > 10% [41.7%]), and regional or distant cancer (stage 3 cancer [27.3%], stage 4 cancer [36.8%]). The gene discussed is CD4; the disease is AIDS.